Celosome Professional Handling Guide: Storage, Preparation, and Sourcing

Celosome, manufactured by the South Korean company ExoCoBio, is a range of cross-linked hyaluronic acid (HA) dermal fillers. For procurement and inventory purposes, it is important for professionals to distinguish between the different presentations available for sourcing. The line is formulated using ExoCoBio’s proprietary HENM (High Elasticity Network Modulus) cross-linking technology, which influences the rheological properties of the gel.

The product range is typically segmented by viscoelasticity to suit different applications. While specific treatment recommendations are outside the scope of this guide, understanding the product variations is key to proper stock management.

Each variant is supplied in a pre-filled syringe, typically 1.1mL, and may be available with or without lidocaine to accommodate different practitioner preferences and regional regulations. When sourcing products, confirming the exact formulation—with or without lidocaine—is a critical step. For clinics that stock a variety of injectables, maintaining a diverse inventory, such as from the general Hyaluronic acid dermal filler catalog, allows practitioners to select the most appropriate product based on its documented characteristics.

Authentic Celosome fillers are supplied in sealed, sterile packaging designed to maintain product integrity. Upon receiving a shipment, professionals must perform a thorough inspection of each box before adding it to their clinic's inventory.

Standard Box Contents:

• One pre-filled 1.1mL Luer-lock syringe with Celosome HA gel.
• Two sterile, single-use needles. The gauge (e.g., 27G, 30G) will vary depending on the product variant's viscosity.
• Traceability labels containing the product name, batch/lot number, and expiration date.
• A product information insert.

Verification Checklist for Clinic Staff:

1. Check the Seal: Confirm that the outer box's tamper-evident seal is intact. A broken or missing seal compromises sterility and authenticity.
2. Match Lot Numbers: The lot number printed on the outer box should match the number on the sterile syringe blister pack and the traceability labels inside.
3. Inspect the Syringe: Through the clear blister pack, visually inspect the syringe. The HA gel should appear clear, homogenous, and free of particulates. Report any discoloration or visible separation to your distributor immediately.
4. Confirm Expiration Date: Verify that the expiration date provides sufficient time for the product to be used. Do not accept products that are close to or past their expiry.

Proper verification is the first line of defense against counterfeit products. This diligence protects the clinic's reputation and ensures that only legitimate, traceable stock is used. The principles of verification are universal across many aesthetic products, as detailed in guides like A Professional's Guide to Verifying Genuine Curenex Lipo.

Correct storage is fundamental to preserving the physicochemical properties of Celosome HA fillers. Improper storage can degrade the cross-linked HA, affecting the gel's viscosity, elasticity, and stability. Adherence to the manufacturer's guidelines is not optional; it is a requirement for professional use.

Temperature Guidelines: The recommended storage temperature for Celosome products is between 2°C and 25°C (36°F and 77°F). This range ensures the stability of the hyaluronic acid polymer chains.

• Do Not Freeze: Freezing the product can cause irreversible damage to the gel structure, forming ice crystals that can fracture the HA network. This may alter the product's performance and safety profile. If a product is suspected of having been frozen, it should be quarantined and not used.
• Avoid Heat and Direct Sunlight: High temperatures and UV radiation can accelerate the degradation of hyaluronic acid. Products should be stored in a designated, temperature-controlled medical cabinet or storage room away from windows and heat sources.

Cold Chain Management: As a wholesale distributor, we ensure that the cold chain is maintained from the point of origin to your clinic. Our logistics protocols include temperature-controlled shipping and handling to guarantee that products like Celosome and other temperature-sensitive injectables arrive within their specified stable temperature range. Upon delivery, it is the clinic's responsibility to immediately transfer the products to appropriate storage conditions.

Celosome fillers are supplied in ready-to-use, pre-filled syringes. The preparation process focuses on ensuring the product is at the correct temperature and that the needle is attached correctly for a safe and smooth procedure. This is not a reconstitution guide, as the product does not require mixing.

Step-by-Step Preparation Reference:

1. Acclimatize to Room Temperature: If the product has been stored at the cooler end of its temperature range (e.g., in a medical refrigerator), it is advisable to let the syringe sit at ambient room temperature for approximately 30 minutes before use. This can help reduce the extrusion force required, providing a smoother injection process for the practitioner.
2. Inspect the Product Again: Before opening the sterile blister pack, re-inspect the syringe for any signs of damage, gel separation, or particulates.
3. Aseptic Technique: Open the blister pack on a sterile field using standard aseptic techniques.
4. Needle Attachment:
   • Remove the protective cap from the Luer-lock tip of the syringe.
   • Select one of the sterile needles provided in the box.
   • Gently screw the needle onto the syringe hub in a clockwise direction until it is securely fitted. Do not overtighten, as this can damage the hub.
   • Carefully remove the needle's protective sheath just before application.
5. Priming: Depress the plunger rod carefully until a small droplet of gel is visible at the needle tip. This confirms that the needle is patent and removes any air from the needle lumen.

The product is now ready for use by a trained and qualified practitioner. Similar handling care is standard for other fillers, including brands like Hyaldew, which also require meticulous preparation.

The practice of diluting hyaluronic acid fillers or mixing them with other substances, such as lidocaine or saline, is considered an off-label modification. Celosome is formulated and sterilized by ExoCoBio to be used as supplied in the pre-filled syringe. Any alteration of the product is solely at the professional discretion and liability of the practitioner.

Considerations for Practitioners:

• Impact on Rheology: Adding any substance will change the gel's original rheological properties. Dilution will decrease its G' (elastic modulus) and viscosity, making the gel softer and more spreadable but potentially reducing its longevity and lifting capacity. The precise outcome is not predictable and is not endorsed by the manufacturer.
• Lidocaine Admixture: Celosome is available in formulations that already contain lidocaine. For practitioners who source the non-lidocaine version, such as the Hyaldew Non-Lidocaine: A Wholesale Sourcing Guide for Aesthe model, and consider adding lidocaine themselves, several factors must be considered. The acidic pH of lidocaine hydrochloride solutions can affect the stability of the HA gel. It also introduces an additional risk of contamination if not performed under strict aseptic conditions.
• Regulatory and Liability: Off-label modification of a medical device may have implications for professional liability and insurance coverage. Practitioners should be fully aware of their local regulations and professional guidelines before altering any pre-packaged, sterile product.

This information is provided for technical reference only. We do not provide protocols for off-label product modification.

Proper disposal of used medical devices is a critical component of clinic safety and regulatory compliance.

Single-Patient Use: Each Celosome syringe is strictly for single-patient use. Do not save or attempt to re-sterilize any remaining product for use on another patient. This practice carries a high risk of cross-contamination and infection and is a violation of professional medical standards.

Disposal Protocol:

1. Do Not Recap Needles: To prevent needlestick injuries, avoid recapping the used needle.
2. Sharps Container: Immediately following the procedure, the used syringe with the needle attached should be disposed of in a designated, puncture-proof sharps container.
3. Medical Waste Management: The sharps container, along with other potentially infectious materials, must be handled and disposed of according to local, regional, and national medical waste regulations. Consult your local health authority or a certified medical waste management service for specific requirements in your jurisdiction.
4. Traceability Records: The traceability labels provided with the product should be affixed to the patient's record. This creates a permanent link between the specific product batch used and the patient, which is essential for quality control and in the rare event of an adverse event investigation or product recall.