Liporase Hyaluronidase: A Professional Reference for Handling and Reconstitution

Liporase, manufactured by the South Korean pharmaceutical company Daehan New Pharm, is a purified hyaluronidase enzyme. Its function is to hydrolyze hyaluronic acid, increasing the permeability of connective tissue and facilitating the dispersion of fluids. In aesthetic medicine, it is used by trained professionals to address complications or undesired results from hyaluronic acid filler injections.

Each vial of Liporase contains 1,500 International Units (I.U.) of hyaluronidase as a lyophilized (freeze-dried) white powder. This format ensures stability and a long shelf life before reconstitution. When sourcing for your clinic, it is a standard offering within the broader Aesthetic accessory catalog, positioned as a necessary adjunct for any practice that administers HA-based injectables.

Verifying the authenticity of medical supplies is a critical step in clinical procurement. Authentic Liporase is typically supplied in a box containing 10 sterile glass vials. Each vial is sealed with a rubber stopper and an aluminum cap.

Upon receiving a shipment, practitioners should perform the following checks:

• Seals: Ensure the vial's aluminum cap and the outer box seals are intact and have not been tampered with.
• Labeling: Check for clear, legible printing that includes the product name (Liporase), manufacturer (Daehan New Pharm), strength (1,500 I.U.), lot number, and expiration date.
• Powder Appearance: The lyophilized powder should be a dry, white, cake-like substance. Any discoloration or signs of moisture may indicate compromised product integrity.

Maintaining a clear procurement record by logging lot numbers is a best practice for inventory management and traceability.

Proper reconstitution is necessary to activate the enzyme for clinical use. The process requires aseptic technique to prevent contamination.

Required Materials:

• One vial of Liporase (1,500 I.U.)
• Sterile 0.9% sodium chloride (bacteriostatic saline) for injection
• Sterile syringe (e.g., 3mL, 5mL, or 10mL, depending on desired dilution)
• Sterile needle for drawing and another for injection, if required by protocol

Reconstitution Steps:

1. Remove the plastic cap from the Liporase vial and disinfect the rubber stopper with an alcohol wipe.
2. Using a sterile syringe, draw up the desired amount of sterile saline. The volume of saline will determine the final concentration of the hyaluronidase solution (see dilution table below).
3. Carefully insert the needle through the center of the rubber stopper and slowly inject the saline into the vial. Direct the stream of saline against the glass wall of the vial to minimize foaming.
4. Gently swirl the vial to dissolve the lyophilized powder. Do not shake vigorously, as this can denature the enzyme. The powder should dissolve completely, resulting in a clear, colorless solution.
5. Visually inspect the solution for any particulate matter or discoloration before use. If any is present, the vial should be discarded.

The reconstituted solution is now ready for professional application according to the practitioner’s established protocols.

The concentration of reconstituted Liporase is determined by the volume of saline used. The choice of dilution is a matter of professional judgment based on the clinical situation, treatment area, and type of HA filler being addressed. The following table provides a reference for calculating concentrations. This is not a recommendation for any specific application.

Some clinical protocols may involve combining the hyaluronidase solution with a local anesthetic to manage patient comfort. Professionals who follow such protocols may source anesthetics like Huons Lidocaine HCI Inj. separately, ensuring all products are handled according to their respective guidelines.

Before Reconstitution: Unopened vials of lyophilized Liporase are stable at room temperature. They should be stored in a dry place, protected from light, at a controlled temperature between 1-30°C (34-86°F). Refrigeration is not required for the powder form.

After Reconstitution: For optimal potency and to minimize the risk of bacterial contamination, reconstituted Liporase should be used immediately. Manufacturer guidelines and clinical best practices advise against storing the solution for extended periods. If immediate use is not possible, the reconstituted solution should be refrigerated at 2-8°C (36-46°F) and used within a short timeframe. [VERIFY: Confirm maximum refrigerated storage duration from manufacturer data sheet, though immediate use is standard protocol]. Discard any unused solution in a single-use vial according to medical waste disposal regulations.

For clinics and distributors, sourcing Liporase involves more than just price. Reliability and product authenticity are paramount. When selecting a wholesale supplier, consider their ability to provide documentation of origin and traceable lot numbers. This level of diligence is similar to that required when sourcing temperature-sensitive products like botulinum toxins, a process detailed in our guide, 'Botulax 300 Units: A Professional Guide for Wholesale Sourci'.

Wholesale pricing for Liporase is often structured in tiers based on volume. For illustrative purposes, a single unit might be priced at $82.0, with discounts applied for larger orders:

• 11+ units: 4% discount
• 21+ units: 5% discount
• 31+ units: 6% discount
• 51+ units: 8% discount

Ensure your supplier has robust inventory and shipping practices to deliver products efficiently and in proper condition.